NNRTIS AND STATINS - DELAVIRDINE
Delavirdine is expected to raise the levels of atorvastatin, simvastatin and lovastatin. This expectation is supported by a case of rhabdomyolysis, which developed in a patient taking atorvastatin and delavirdine.
One of the manufacturers of simvastatin contraindicates delavirdine, and the US manufacturer of delavirdine advises against the use of either simvastatin or lovastatin. Patients should be made aware of the risks of myopathy and rhabdomyolysis, and asked to promptly report muscle pain, tenderness or weakness, especially if accompanied by malaise, fever or dark urine.
One of the manufacturers of simvastatin contraindicates delavirdine, and the US manufacturer of delavirdine advises against the use of either simvastatin or lovastatin. Patients should be made aware of the risks of myopathy and rhabdomyolysis, and asked to promptly report muscle pain, tenderness or weakness, especially if accompanied by malaise, fever or dark urine.