NRTIS AND PHENYTOIN
Phenytoin is predicted to decrease abacavir levels. Zidovudine may alter the pharmacokinetics of phenytoin, although this may be due to HIV infection itself. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
The clinical significance of these interactions is unclear. However, it may be prudent to monitor the efficacy of abacavir. Be aware that larger phenytoin doses may be needed in the presence of zidovudine.
The clinical significance of these interactions is unclear. However, it may be prudent to monitor the efficacy of abacavir. Be aware that larger phenytoin doses may be needed in the presence of zidovudine.