NRTIS AND PROBENECID
Probenecid reduces the clearance of zalcitabine and zidovudine, increasing their serum levels.
The combination of zalcitabine and probenecid is well tolerated, but the incidence of adverse effects is reported to be very much increased when probenecid is taken with zidovudine. Concurrent use need not be avoided, but monitor carefully for zidovudine toxicity.
The combination of zalcitabine and probenecid is well tolerated, but the incidence of adverse effects is reported to be very much increased when probenecid is taken with zidovudine. Concurrent use need not be avoided, but monitor carefully for zidovudine toxicity.