NRTIS AND VALPROATE
Sodium valproate increases the AUC of zidovudine by 80%. In one case sodium valproate increased serum zidovudine levels by up to 3-fold, and increased the CSF levels of zidovudine by 74%.
It would seem prudent to monitor for zidovudine adverse effects and possible toxicity. Other NRTIs do not undergo significant glucuronidation and are therefore not expected to interact in this way with sodium valproate.
It would seem prudent to monitor for zidovudine adverse effects and possible toxicity. Other NRTIs do not undergo significant glucuronidation and are therefore not expected to interact in this way with sodium valproate.