NSAIDS AND PARACETAMOL (ACETAMINOPHEN)
On the whole the concurrent use of NSAIDs with paracetamol is beneficial and without serious adverse effects. However, one epidemiological study found that paracetamol alone, and particularly when combined with NSAIDs, was associated with an increased risk of gastrointestinal bleeding, but other studies have not found such an effect. Diflunisal raises paracetamol levels by 50% but does not alter the total bioavailability.
The interaction with diflunisal has not been shown to be clinically significant but the manufacturers advise caution because of the risks of increased paracetamol levels. There is no evidence to suggest that the concurrent use of paracetamol and any NSAID should be avoided.
The interaction with diflunisal has not been shown to be clinically significant but the manufacturers advise caution because of the risks of increased paracetamol levels. There is no evidence to suggest that the concurrent use of paracetamol and any NSAID should be avoided.