NSAIDS AND PENICILLAMINE
Indometacin has been found to increase the peak levels of penicillamine by about 22%. The manufacturers warn that the concurrent use of NSAIDs and penicillamine may increase the risk of nephrotoxicity.
The US manufacturer specifically recommends avoiding oxyphenbutazone or phenylbutazone because these drugs are also associated with serious haematolo- gical and renal effects. There seems to be no reason to avoid other NSAIDS and penicillamine, but if problems occur bear the possibility of a drug interaction in mind.
The US manufacturer specifically recommends avoiding oxyphenbutazone or phenylbutazone because these drugs are also associated with serious haematolo- gical and renal effects. There seems to be no reason to avoid other NSAIDS and penicillamine, but if problems occur bear the possibility of a drug interaction in mind.