NSAIDS AND SSRIS
The SSRIs may increase the risk of upper gastrointestinal bleeding and the risk appears to be further increased by the concurrent use of NSAIDs.
The manufacturers of the SSRIs warn that patients should be cautioned about the
concurrent use of NSAIDs. Alternatives such as paracetamol (acetaminophen) or less gastrotoxic NSAIDs such as ibuprofen may be considered, but if the combination of an SSRI and NSAID cannot be avoided, prescribing of gastro-protective drugs such as proton pump inhibitors, or H2-receptor antagonists should be considered, especially in elderly patients or those with a history of gastrointestinal bleeding.
The manufacturers of the SSRIs warn that patients should be cautioned about the
concurrent use of NSAIDs. Alternatives such as paracetamol (acetaminophen) or less gastrotoxic NSAIDs such as ibuprofen may be considered, but if the combination of an SSRI and NSAID cannot be avoided, prescribing of gastro-protective drugs such as proton pump inhibitors, or H2-receptor antagonists should be considered, especially in elderly patients or those with a history of gastrointestinal bleeding.