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NSAIDS AND TICLOPIDINE

Medical Diagnosis and Drugs, Medications
The risk of faecal blood loss, gastrointestinal haemorrhage and other bleeding is increased by concurrent use of clopidogrel and NSAIDs. Ticlopidine is expected to interact similarly.
The manufacturers advise caution if NSAIDs and ticlopidine are given together. Consider giving additional gastrointestinal prophylaxis such as a proton pump inhibitor in patients at risk of gastrointestinal ulceration and bleeding.
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