NSAIDS AND WARFARIN AND OTHER ORAL ANTICOAGULANTS - COXIBS

There is some evidence to suggest that celecoxib, parecoxib and rofecoxib do not normally interact with warfarin. However, raised INRs accompanied by bleeding, particularly in the elderly, have been attributed to the use of warfarin and celecoxib or rofecoxib, and fluindione with rofecoxib. Etoricoxib causes a small increase in INR when it is taken with warfarin.
Monitor the anticoagulant effect if these NSAIDs are added to or withdrawn from
the treatment of patients taking anticoagulants.