ONDANSETRON (ZOFRAN)
Ondansetron (Zofran); Antiemetic; Inj: 2 mg/mL
Soln: 4 mg/5 mL
Tab: 4, 8, 24 mg
Tab, orally disintegrating: 4, 8 mg; Chemotherapy Induced Nausea (IV): 0.15 mg/kg/dose (usual adult max 8 mg) given 30 min prior to chemotherapy
and 4 hr and 8 hr later or 0.3 mg/kg/dose x 1 thirty minutes prior to chemotherapy or for severe cases, 0.15 mg/kg x 1, followed by 0.45 mg/kg/day
(max 32 mg/day) as a continuous IV infusion
Post-op nausea and vomiting (IV): >2 yrs and <40 kg: 0.1 mg/kg IV x 1, >40 kg: 4 mg IV x 1
Oral: 4-11 yrs: 4 mg/dose PO 30 min prior to chemotherapy; may repeat 4h and 8h after 1st dose
>11 yrs: 8 mg/dose PO 30 min prior to chemotherapy; may repeat 4h and 8h after 1st dose
Most frequent side effects are diarrhea and headache. The orally disintegrating tablets dissolve on the tongue without any water.
Soln: 4 mg/5 mL
Tab: 4, 8, 24 mg
Tab, orally disintegrating: 4, 8 mg; Chemotherapy Induced Nausea (IV): 0.15 mg/kg/dose (usual adult max 8 mg) given 30 min prior to chemotherapy
and 4 hr and 8 hr later or 0.3 mg/kg/dose x 1 thirty minutes prior to chemotherapy or for severe cases, 0.15 mg/kg x 1, followed by 0.45 mg/kg/day
(max 32 mg/day) as a continuous IV infusion
Post-op nausea and vomiting (IV): >2 yrs and <40 kg: 0.1 mg/kg IV x 1, >40 kg: 4 mg IV x 1
Oral: 4-11 yrs: 4 mg/dose PO 30 min prior to chemotherapy; may repeat 4h and 8h after 1st dose
>11 yrs: 8 mg/dose PO 30 min prior to chemotherapy; may repeat 4h and 8h after 1st dose
Most frequent side effects are diarrhea and headache. The orally disintegrating tablets dissolve on the tongue without any water.