OPIOIDS AND PROTEASE INHIBITORS - METHADONE
Methadone serum levels can be reduced by amprenavir, nelfinavir, lopinavir/ritonavir, ritonavir/saquinavir, tipranavir/ritonavir and possibly ritonavir. Not all patients appear to be affected. Amprenavir levels may be reduced by methadone.
An increased methadone dosage may be needed in some patients to prevent opiate withdrawal. Monitor amprenavir to ensure it remains effective. It has been suggested that alternative antiretrovirals should be considered.
An increased methadone dosage may be needed in some patients to prevent opiate withdrawal. Monitor amprenavir to ensure it remains effective. It has been suggested that alternative antiretrovirals should be considered.