OPIOIDS AND PROTEASE INHIBITORS - PETHIDINE (MEPERIDINE)
Ritonavir decreased pethidine levels but increased norpethidine levels, which may possibly increase toxicity on long-term use.
The manufacturers of pethidine oral preparations and injection contraindicate or advise against its use with ritonavir because of the risk of norpethidine toxicity. Long-term use of pethidine with other protease inhibitors that are given with low- dose ritonavir is also not recommended.
The manufacturers of pethidine oral preparations and injection contraindicate or advise against its use with ritonavir because of the risk of norpethidine toxicity. Long-term use of pethidine with other protease inhibitors that are given with low- dose ritonavir is also not recommended.