OPIOIDS AND SSRIS - OTHER OPIOIDS
In isolated cases the concurrent use of SSRIs and opioids (including fentanyl, hydromorphone, oxycodone, pentazocine, pethidine (meperidine), and possibly morphine) has resulted in the serotonin syndrome. Methadone levels are modestly increased by fluvoxamine, paroxetine and sertraline, and possibly fluoxetine.
Serotonin syndrome, seems to be a rare occurrence, but the possibility should be borne in mind if an SSRI is given with one of these opioids. Be aware that the use of fluvoxamine, paroxetine, sertraline or fluoxetine may alter the response to methadone. Monitor the outcome of concurrent use for methadone adverse effects.
Serotonin syndrome, seems to be a rare occurrence, but the possibility should be borne in mind if an SSRI is given with one of these opioids. Be aware that the use of fluvoxamine, paroxetine, sertraline or fluoxetine may alter the response to methadone. Monitor the outcome of concurrent use for methadone adverse effects.