OPIOIDS AND TRIPTANS
Sumatriptan given by injection appears not to interact with butorphanol nasal spray, but if both drugs are given by nasal spray a significant interaction may occur, resulting in a reduction in butorphanol levels.
When butorphanol was given 30 minutes after sumatriptan no significant pharmacokinetic interaction was noted. It would therefore seem wise to separate administration to ensure the full effects of butorphanol are achieved.
When butorphanol was given 30 minutes after sumatriptan no significant pharmacokinetic interaction was noted. It would therefore seem wise to separate administration to ensure the full effects of butorphanol are achieved.