OXCARBAZEPINE AND PHENYTOIN
High doses of oxcarbazepine increase phenytoin levels, and a reduction in the phenytoin dose may be required. Elevations in phenytoin levels of up to 40% have been seen in retrospective studies. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
Bear this interaction in mind on concurrent use, and with high oxcarbazepine doses consider monitoring phenytoin levels. Indicators of phenytoin toxicity include blurred vision, nystagmus, ataxia or drowsiness.
Bear this interaction in mind on concurrent use, and with high oxcarbazepine doses consider monitoring phenytoin levels. Indicators of phenytoin toxicity include blurred vision, nystagmus, ataxia or drowsiness.