PARACETAMOL (ACETAMINOPHEN) AND RIFAMPICIN (RIFAMPIN)
Rifampicin induces the glucuronidation of paracetamol and increases its clearance, but does not increase the formation of hepatotoxic metabolites of paracetamol.
The clinical importance of these findings awaits further study, but they suggest that rifampicin may reduce the efficacy of paracetamol.
The clinical importance of these findings awaits further study, but they suggest that rifampicin may reduce the efficacy of paracetamol.