PENTOXIFYLLINE AND QUINOLONES
Evidence from one study suggests that ciprofloxacin increases the peak serum levels of pentoxifylline by 60%, and may increase the incidence of adverse effects. In some clinical studies ciprofloxacin has been used to boost the levels of pentoxifylline.
It has been suggested that the dosage of pentoxifylline should be halved if ciprofloxacin is also given, which may be a sensible precaution. Alternatively, it may be sufficient to recommend a reduction in pentoxifylline dose only in those who experience adverse effects (e.g. nausea, headache). Note that other quinolones may also interact, see quinolones.
It has been suggested that the dosage of pentoxifylline should be halved if ciprofloxacin is also given, which may be a sensible precaution. Alternatively, it may be sufficient to recommend a reduction in pentoxifylline dose only in those who experience adverse effects (e.g. nausea, headache). Note that other quinolones may also interact, see quinolones.