PENTOXIFYLLINE AND WARFARIN AND OTHER ORAL ANTICOAGULANTS

The anticoagulant effects of phenprocoumon were not significantly altered by pentoxifylline in one study, but serious bleeding has been seen with pentoxifylline, both alone and in the presence of acenocoumarol. Other oral anticoagulants would be expected to interact similarly.
It may be prudent to monitor concurrent use for any increase in bleeding events. Some have suggested the combination should be avoided.