PHENOBARBITAL AND PROPAFENONE
Phenobarbital reduces the peak levels of propafenone by 26 to 87%. Primidone is metabolised to phenobarbital and may therefore interact similarly.
The clinical importance of this interaction awaits assessment but check that propafenone remains effective if phenobarbital is added, and that toxicity does not occur if it is stopped.
The clinical importance of this interaction awaits assessment but check that propafenone remains effective if phenobarbital is added, and that toxicity does not occur if it is stopped.