PHENOBARBITAL AND SIROLIMUS
The manufacturers of sirolimus predict that phenobarbital (and therefore probably primidone) may lower its serum levels, probably because rifampicin (rifampin), another CYP3A4 inducer, has been shown to do so.
The extent of any change in sirolimus levels is uncertain, but it would seem prudent to increase the frequency of monitoring of sirolimus levels during concurrent use.
The extent of any change in sirolimus levels is uncertain, but it would seem prudent to increase the frequency of monitoring of sirolimus levels during concurrent use.