PHENOBARBITAL AND TIAGABINE
The plasma concentration of tiagabine may be reduced by 1.5- to 3-fold by both phenobarbital and primidone.
The manufacturers recommend that tiagabine 30 to 45 mg (in divided doses) should be given to patients taking enzyme-inducing antiepileptics.
The manufacturers recommend that tiagabine 30 to 45 mg (in divided doses) should be given to patients taking enzyme-inducing antiepileptics.