PHENOBARBITAL AND TRICYCLICS
Barbiturates reduce the levels of the tricyclic antidepressants, which has been associated with the re-emergence of depression. Although not all combinations have been studied, they would all be expected to interact similarly.
Monitor the outcome of concurrent use anticipating reduced tricyclic antidepres- sant effects. Consider an alternative to the barbiturate, or raise the tricyclic dose if problems occur. Note that tricyclics lower the seizure threshold.
Monitor the outcome of concurrent use anticipating reduced tricyclic antidepres- sant effects. Consider an alternative to the barbiturate, or raise the tricyclic dose if problems occur. Note that tricyclics lower the seizure threshold.