PHENYTOIN AND QUINOLONES
Studies suggest that ciprofloxacin, clinafloxacin, and enoxacin do not usually have a clinically significant effect on phenytoin levels. However, case reports describe both a rise and a fall in phenytoin levels in patients given ciprofloxacin. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
The clinical importance of these changes in levels is unknown, but bear them in mind in case of an unexpected response to treatment. It has been suggested that it may be prudent to monitor phenytoin levels in those given ciprofloxacin. Quinolones alone very occasionally cause convulsions, therefore they should be used with caution in patients with epilepsy.
The clinical importance of these changes in levels is unknown, but bear them in mind in case of an unexpected response to treatment. It has been suggested that it may be prudent to monitor phenytoin levels in those given ciprofloxacin. Quinolones alone very occasionally cause convulsions, therefore they should be used with caution in patients with epilepsy.