PHENYTOIN AND TICLOPIDINE
There are a number of case reports of patients taking phenytoin who developed toxicity when ticlopidine was added. Ticlopidine appears to inhibit phenytoin metabolism. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
It would be prudent to monitor serum phenytoin levels if ticlopidine is added. Warn the patient to monitor for indicators of phenytoin toxicity (blurred vision, nystagmus, ataxia or drowsiness).
It would be prudent to monitor serum phenytoin levels if ticlopidine is added. Warn the patient to monitor for indicators of phenytoin toxicity (blurred vision, nystagmus, ataxia or drowsiness).