PHENYTOIN AND VACCINES
Influenza vaccine is reported to increase, decrease or to have no effect on the serum levels of phenytoin. Fosphenytoin, a prodrug of phenytoin, may interact similarly. The efficacy of the vaccine is unaffected.
Phenytoin levels appear to return to normal after about 14 days. Warn the patient to monitor for indicators of phenytoin toxicity (blurred vision, nystagmus, ataxia or drowsiness). However, be aware that any alteration in levels may take a couple of weeks to develop and usually resolves spontaneously.
Phenytoin levels appear to return to normal after about 14 days. Warn the patient to monitor for indicators of phenytoin toxicity (blurred vision, nystagmus, ataxia or drowsiness). However, be aware that any alteration in levels may take a couple of weeks to develop and usually resolves spontaneously.