PRAVASTATIN, OR ROSUVASTATIN
CYP3A4 is not the main enzyme involved in the metabolism of pravastatin, or rosuvastatin, and so no interaction would generally be expected. However, rare cases of rhabdomyolysis have been reported in patients given one of these statins with an azole.
Because of the potentially serious reactions that can result, any patient given pravastatin or rosuvastatin with an azole should be told to report any unexplained muscle pain, tenderness or weakness.
Because of the potentially serious reactions that can result, any patient given pravastatin or rosuvastatin with an azole should be told to report any unexplained muscle pain, tenderness or weakness.