PROBENECID AND PYRAZINAMIDE

The interactions of probenecid and pyrazinamide and their effects on the excretion of uric acid are complex. The overall effect is that if probenecid were to be used to treat the hyperuricaemia caused by pyrazinamide, the normal uricosuric effects of probenecid would be diminished and larger doses would be required.
Note that hyperuricaemia is a contraindication to pyrazinamide use and it should be stopped if gouty arthritis occurs.