PROPAFENONE AND RIFAMPICIN (RIFAMPIN)
When given orally, propafenone serum levels can be markedly reduced by rifampicin (bioavailability reduced by at least half). This has resulted in the re-emergence of arrhythmias in some cases. Limited evidence suggests that intravenous propafenone is not affected.
The dosage of oral propafenone will probably need increasing if rifampicin is given. Alternatively, if possible, it has been advised that another antibacterial be used because of the probable difficulty in adjusting the propafenone dosage.
The dosage of oral propafenone will probably need increasing if rifampicin is given. Alternatively, if possible, it has been advised that another antibacterial be used because of the probable difficulty in adjusting the propafenone dosage.