PROPAFENONE AND WARFARIN AND OTHER ORAL ANTICOAGULANTS
The anticoagulant effects of warfarin are increased by propafenone (mean 7 second rise in prothrombin time, which was considered to be clinically significant). Case reports suggest that phenprocoumon and fluindione interact similarly.
Monitor the anticoagulant effect if propafenone is added or withdrawn. This interaction appears to start in the first week of concurrent use.
Monitor the anticoagulant effect if propafenone is added or withdrawn. This interaction appears to start in the first week of concurrent use.