PROTEASE INHIBITORS AND RIFAMPICIN (RIFAMPIN)
Rifampicin bioavailability is increased by indinavir, but amprenavir has no effect. Rifampicin markedly reduces the bioavailability of amprenavir, atazanavir, indinavir, lopinavir, nelfinavir and saquinavir.
The use of many of the protease inhibitors with rifampicin is contraindicated. The treatment of tuberculosis in patients taking antiretrovirals is complex and up-to- date guidelines should be consulted.
The use of many of the protease inhibitors with rifampicin is contraindicated. The treatment of tuberculosis in patients taking antiretrovirals is complex and up-to- date guidelines should be consulted.