PROTEASE INHIBITORS AND STATINS - ATORVASTATIN
The levels of atorvastatin appear to be markedly increased by darunavir/ritonavir, lopinavir/ritonavir, nelfinavir, and saquinavir/ritonavir. The manufacturers of ataza- navir/ritonavir and amprenavir state that they may also increase atorvastatin levels.
It is generally recommended that atorvastatin is used at low doses (i.e. 10 mg) and with care in patients taking protease inhibitors. Patients should be counselled regarding myopathy (e.g. report any unexplained muscle pain, tenderness or weakness). The manufacturers of atazanavir and tipranavir advise avoiding concurrent use.
It is generally recommended that atorvastatin is used at low doses (i.e. 10 mg) and with care in patients taking protease inhibitors. Patients should be counselled regarding myopathy (e.g. report any unexplained muscle pain, tenderness or weakness). The manufacturers of atazanavir and tipranavir advise avoiding concurrent use.