PROTEASE INHIBITORS AND TACROLIMUS
Protease inhibitors are predicted to inhibit the metabolism of tacrolimus and increase its blood levels. Case reports have described this interaction with lopinavir, nelfinavir and saquinavir/ritonavir.
When protease inhibitors are given to patients taking tacrolimus, careful monitoring and probably a reduction in the dose of tacrolimus is required. Note that in one case tacrolimus was dosed just once weekly to achieve appropriate levels.
When protease inhibitors are given to patients taking tacrolimus, careful monitoring and probably a reduction in the dose of tacrolimus is required. Note that in one case tacrolimus was dosed just once weekly to achieve appropriate levels.