PROTEASE INHIBITORS AND TRAZODONE
Ritonavir increases the AUC of trazodone by more than 2-fold and sedation and
fatigue were increased. Two cases of serotonin syndrome, have been reported in patients taking trazodone and ritonavir or indinavir. Other protease inhibitors may interact similarly.
A lower dose of trazodone should be considered if it is given with potent CYP3A4
inhibitors such as ritonavir and indinavir, although note that in the UK it has been
suggested that the combination should be avoided where possible.
fatigue were increased. Two cases of serotonin syndrome, have been reported in patients taking trazodone and ritonavir or indinavir. Other protease inhibitors may interact similarly.
A lower dose of trazodone should be considered if it is given with potent CYP3A4
inhibitors such as ritonavir and indinavir, although note that in the UK it has been
suggested that the combination should be avoided where possible.