PROTEASE INHIBITORS AND TRIPTANS

The manufacturer of eletriptan predicts that indinavir, nelfinavir and ritonavir will increase eletriptan levels. This seems reasonable, based on the way other CYP3A4 inhibitors interact. It seems possible that all protease inhibitors may interact, although probably to a lesser degree.
The manufacturers of eletriptan say that the concurrent use of indinavir, nelfinavir and ritonavir should be avoided.