SSRIS AND TACRINE
Fluvoxamine can increase the AUC of tacrine by up to 8-fold. Tacrine adverse effects (nausea, vomiting, diarrhoea, sweating) are increased.
A decrease in the tacrine dose is likely to be needed. Other SSRIs such as fluoxetine, paroxetine, or sertraline may be suitable alternatives, as these are unlikely to inhibit tacrine metabolism.
A decrease in the tacrine dose is likely to be needed. Other SSRIs such as fluoxetine, paroxetine, or sertraline may be suitable alternatives, as these are unlikely to inhibit tacrine metabolism.