SSRIS AND THEOPHYLLINE
Theophylline serum levels can be markedly and rapidly increased by the concurrent use of fluvoxamine. Toxicity has occurred.
Ideally concurrent use should be avoided. If this is not possible, reduce the theophylline dose and monitor theophylline levels. Some preliminary clinical evidence suggests that fluoxetine and citalopram (and therefore probably escitalopram) may not interact with theophylline, and in vitro evidence suggests that paroxetine and sertraline are also unlikely to interact. They may therefore be suitable alternatives.
Ideally concurrent use should be avoided. If this is not possible, reduce the theophylline dose and monitor theophylline levels. Some preliminary clinical evidence suggests that fluoxetine and citalopram (and therefore probably escitalopram) may not interact with theophylline, and in vitro evidence suggests that paroxetine and sertraline are also unlikely to interact. They may therefore be suitable alternatives.