SSRIS AND TRIPTANS
The concurrent use of a triptan and an SSRI is normally uneventful, but adverse reactions (such as serotonin syndrome, reported with sumatriptan and some SSRIs) do occasionally occur. Fluvoxamine has been shown to increase the blood levels of frovatriptan by 27 to 49%, and is predicted to increase the levels of zolmitriptan.
The combination need not be avoided, but monitor carefully, especially if other serotonergic drugs are also used. The manufacturers of zolmitriptan recommend a dosage reduction to a maximum of 5 mg in 24 hours in the presence of fluvoxamine.
The combination need not be avoided, but monitor carefully, especially if other serotonergic drugs are also used. The manufacturers of zolmitriptan recommend a dosage reduction to a maximum of 5 mg in 24 hours in the presence of fluvoxamine.