SSRIS AND TRYPTOPHAN
Central and peripheral toxicity developed in a number of patients taking fluoxetine with tryptophan. On theoretical grounds an adverse reaction (such as serotonin syndrome) seems possible between any SSRI and tryptophan.
The combination is probably best avoided, as advised by the manufacturers of tryptophan. If tryptophan is given with an SSRI, the SSRI should be started at a low dose and tryptophan gradually introduced starting with a low dose. Patients should be closely monitored for adverse effects.
The combination is probably best avoided, as advised by the manufacturers of tryptophan. If tryptophan is given with an SSRI, the SSRI should be started at a low dose and tryptophan gradually introduced starting with a low dose. Patients should be closely monitored for adverse effects.