TERBINAFINE AND VENLAFAXINE
The metabolism of venlafaxine to its active metabolite O-desmethylvenlafaxine is reduced in the presence of terbinafine. However, the combined AUC of venlafaxine and its metabolite is only raised by a modest 22%.
Until more is known, it may be prudent to be alert for any indication of increased venlafaxine adverse effects (e.g. nausea, insomnia, dry mouth) in patients also taking terbinafine.
Until more is known, it may be prudent to be alert for any indication of increased venlafaxine adverse effects (e.g. nausea, insomnia, dry mouth) in patients also taking terbinafine.