ZIDOVUDINE (AZT, RETROVIR, ZDV)

Zidovudine (AZT, Retrovir, ZDV); Antiretroviral, Nucleoside Analog Reverse Transcriptase Inhibitor; Cap: 100 mg
Inj: 10 mg/mL
Syr: 10 mg/mL
Tab: 300 mg; <2 wks: 2 mg/kg/dose PO q6h, or 1.5 mg/kg/dose IV q6h
2-4 wks: 3 mg/kg/dose PO q6h, or 2.25 mg/kg/dose IV q6h
4 wks - 12 yrs: 90-180 mg/m2/dose PO q6h (max 200 mg/dose), or 0.5-1.8 mg/kg/hr continuous IV infusion, or 100-120 mg/m2/dose IV q6h
>12 yrs:
Monotherapy and symptomatic: 100 mg PO q4h or 200 mg PO q8h
Monotherapy and asymptomatic: 100 mg PO q4h while awake (500 mg/day)
Combination therapy: 200 mg PO q8h or 1 mg/kg/dose IV q4h
Most common side effects include anemia, agranulocytopenia, and increased liver function tests.